- The character of Jeffrey Beaumont was originally offered to Val Kilmer, who rejected it claiming that the script that had read was like pornography, but after seeing the film said that he would have liked to make it, Since it was not how he imagined after reading the script.
- Many of the actors who was offered the role of Frank found the character too repulsive and intense. Dennis Hopper, on the other hand, exclaimed: “I have to get the role of Frank. Because I am Frank!.”
- Lynch initially wanted Frank to inhaled helium during his scene of sex with Dorothy.